The investigation, which was published in the British medical journal The Lancet, analyzed the outcome of injections with additional doses in people who took two doses of the Oxford/AstraZeneca vaccine, used in more than 180 countries, and Pfizer/BioNtech, in more than 145. The anabolic steroid is “safe and enhances the immune response.”
However, it has not been found to be more effective at “protecting against infection or serious illness.”
“The side effect data show that the seven vaccines analyzed are safe for use as third doses, with acceptable levels of inflammatory secondary effects such as pain at the vaccination site, muscle aches and fatigue. Although all vaccines had increased immunity after two doses of Astrazeneca, only AstraZeneca, Pfizer-BioNtech, Moderna, Novavax, Janssen and Curevac achieved the same thing after two doses of Pfizer-BioNtech, said researcher Paul Faust, of University Hospital in Southampton, UK.
As a starting point, the effectiveness of these vaccines is known to decrease over time.
The third doses were given to study participants 10 to 12 weeks after they received the second dose of the vaccine.
Increases in antibody production against a protein that SARS-CoV-2 uses to penetrate cells ranged from 1.8- to 32.3-fold in people who took two doses of AstraZeneca and 1.3 to 11.5-fold in people vaccinated with Pfizer/BioNtech, with a “significant response” In the increase of immune T cells in different groups.
“It is important to note that the results only indicate the use of these vaccines as a booster for the initial vaccination and the immune response achieved up to 28 days thereafter. Further research will be needed after three months and one year of booster doses, which will provide data on the effect on protection for a long time. Range and immune memory. We are also studying the effect of two vaccines in people who took a booster dose after seven to eight months, but the results won’t be available until next year,” he added.
2,878 people aged 30 or older took part in the study. More than 900 in total over a thousand adverse effects were reported in addition to the most common (fatigue, headache, pain at the injection site), 24 of which were serious.
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