Antiaging protein improves cognition and memory in rhesus monkeys – Jornal da USP

seek published in the journal nature aging by American scientists showed that a protein called klotho improves cognitive function and memory in monkeys. Named after the Greek goddess Klotho—who wove the threads of life in Greek mythology—this substance occurs naturally in our bodies, but decreases with age.

In the experiment, the researchers tested the effect of small doses of klotho in rats and rhesus monkeys. The monkeys were about 22 years old and given a single injection of the protein. “The advantage of monkeys, as it is known, is that they are 93% similar to humans and have a higher and more complex cognitive function. In addition, they also have cognitive decline with age and changes in synapses, which damages areas of the brain, including the hippocampus and prefrontal cortex explains Mayana Zatz, director of the Center for Human Genome and Stem Cell Studies (CEGH-CEL) of USP.

The hippocampus is the area of ​​the brain responsible for forming new memories, as well as being associated with learning and emotions. The prefrontal cortex is the area associated with intelligence, logical thinking, and manipulation in other areas of the brain.

The researchers had two goals: to find out whether increases in serum levels (i.e., the amount) of klotho, compared to those seen in mice, lead to improved cognitive ability in monkeys. To check whether larger doses of protein have a greater effect on cognitive ability, ie whether the effect is dose dependent.

Klotho is already known for its neuroprotective effect and its ability to improve memory. Previous research had already been done on mice, but this is the first time the research has been done on monkeys. “While our group studies centenarians, this topic interests us a lot,” says the geneticist.

The result of animal evaluations and questions that continue to be asked after research conclusions have been presented by a geneticist.

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